Purification and subunit structure of hepatocyte growth factor from rat platelets
نویسندگان
چکیده
منابع مشابه
Purification, Characterization, and Subunit Structure of Rat
The O-linked oligosaccharides (O-glycans) in mammalian glycoproteins are classified according to their core structures. Among the most common is the core 1 disaccharide structure consisting of Gal 133GalNAc 13Ser/ Thr, which is also the precursor for many extended Oglycan structures. The key enzyme for biosynthesis of core 1 O-glycan from the precursor GalNAc-Ser/Thr is UDP-Gal:GalNAc-Ser/Thr 3...
متن کاملPartial purification and characterization of a hepatocyte growth factor produced by rat hepatocellular carcinoma cells.
Serum-free medium conditioned by confluent cultures of JM1 of JM2 rat hepatocellular carcinoma cells stimulated DNA synthesis in primary cultures of adult rat hepatocytes in a dose-dependent, saturable manner and in the absence of epidermal growth factor. The hepatotrophic activity was nondialyzable in Mr 50,000 cutoff membranes, heat (60 degrees C) and acid stable, and sensitive to trypsin and...
متن کاملPartial Purification and Characterization of a Hepatocyte Growth Factor Produced by Rat Hepatocellular Carcinoma Cells1
Serum-free medium conditioned by confluent cultures of JM1 or JM2 rat hepatocellular carcinoma cells stimulated DMA syn thesis in primary cultures of adult rat hepatocytes in a dosedependent, saturable manner and in the absence of epidermal growth factor. The hepatotrophic activity was nondialyzable in Mr 50,000 cutoff membranes, heat (60°C)and acid stable, and sensitive to trypsin and dithiot...
متن کاملHepatocyte growth factor, hepatocyte growth factor activator and arginine in a rat fulminant colitis model.
INTRODUCTION Dextran sodium sulfate (DSS) is commonly used to induce a murine fulminant colitis model. Hepatocyte growth factor (HGF) has been shown to decrease the symptoms of inflammatory bowel disease (IBD) but the effect of its activator, HGFA, is not well characterized. Arginine reduces effects of oxidative stress but its effect on IBD is not well known. The primary aim is to determine whe...
متن کاملThe Effect of Hepatocyte Growth Factor on Learning and Memory Abilities in a Rat Model of Kainate-Induced Epilepsy
Background and Objective: Epilepsy as a chronic neurological disorder causes inherent seizures and learning and memory failure. Since there is no acceptable control of seizures in some patients with the current recommended drug therapy, new medications with different mechanisms of action are needed. Here, the beneficial effect of hepatocyte growth factor (HGF) was evaluated in an experimental m...
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ژورنال
عنوان ژورنال: FEBS Letters
سال: 1987
ISSN: 0014-5793
DOI: 10.1016/0014-5793(87)80475-1